Research into the biology of RDH12 and how it causes LCA has been extremely limited to date. But
there is good work being conducted in select research laboratories. And with your help, we will drive
and expand this research so that we can better understand and cure LCA caused by mutations in
RDH12.
The success of the RPE65 gene therapy gives hope to those with
other forms of LCA. The before and after videos of young Corey
Haas shows what can be done once the tools are in place.
The Who's Who of RDH12 Research
Anne Kasus-Jacobi
Research Assistant Professor, Department
of Ophthalmology
University of Oklahoma
Characterized the RDH12 knock out mouse
for light-induced cell death
Debra Thompson
Professor, Department of Biochemistry
University of Michigan
Created the RDH12 knock out mouse
Krzysztof Palczewski
Professor and Chair, Department of
Pharmacology
Case Western Reserve University
Leader in understanding retinol signaling
Jean Bennett
Professor, F. M. Kirby Center for Molecular
Ophthalmology
University of Pennsylvania
Led development of the successful LCA gene
therapy effort
Edwin Stone
Professor of Ophthalmology
University of Iowa
Leading lab for genetic diagnosis of LCA
